Issue 9/2025
Reshkova, V.
Clinic of Rheumatology, University Hospital “St. Ivan Rilski”
Immunomodulatory biologic agents are proteins derived from human genes that are genetically engineered to inhibit precise components of the immune system. They suppress specific pathways that play a pivotal role in pathogenesis and, hence, differ from the more commonly used DMARDs, which have broader targets. If tolerated, biologic agents are used in combination with methotrexate, or an alternative DMARD, in view of enhanced efficacy.
Key words: Rheumatic diseases, Biologic agents
Address for correspondence:
Reshkova, V.
Clinic of Rheumatology,
University Hospital “St. Ivan Rilski”
13, „Urvich“, Str.
1612, Sofia