Issue 5/2026
E. Daskalova
Department of Anatomy, Histology and Embryology, Medical University – Plovdiv
Background: Cardiovascular diseases remain the leading cause of mortality worldwide, with aging and chronic inflammation playing a central role. Functional foods rich in bioactive compounds are emerging as complementary preventive strategies. Aim: To evaluate the biochemical composition, mechanisms, and experimental evidence of the cardioprotective effects of Aronia melanocarpa. Materials and Methods: Review of literature and original experimental data from studies on naturally aged rats supplemented with Aronia melanocarpa products. Results: Aronia melanocarpa is rich in anthocyanins, flavonoids, and phenolic acids with potent antioxidant and anti-inflammatory properties. It inhibits the NF-κB pathway, reduces pro-inflammatory cytokines, and improves endothelial function by enhancing nitric oxide bioavailability. Favorable effects on lipid profile, blood pressure, and platelet activity are observed. Experimental findings demonstrate increased ACE2 expression, activation of the ACE2/MAS axis, elevated CD34+ cell levels, and enhanced myocardial neovascularization, accompanied by attenuation of age-related vascular and myocardial remodeling. Conclusion: Aronia melanocarpa is a promising natural cardioprotective agent with pleiotropic effects and potential for use in the prevention and long-term management of cardiovascular risk.
Key words: Aronia melanocarpa; cardioprotection; endothelial function; angiogenesis; cardiovascular diseases
Adress for correspondence:
Dr. Elena Daskalova
Department of Anatomy,
Histology and Embryology
Medical University – Plovdiv
15 A V. Aprilov Blvd.
4000, Plovdiv
e-mail: elena.daskalova@mu-plovdiv.bg