Issue 7/2022
K. Drenovska, D. Serafimova, M. Shahid, L. Miteva, S. Vassileva
Department of Dermatology and Venereology, Medical University – Sofia
Paraneoplastic pemphigus (PNP), also called Paraneoplastic Autoimmune Multiorgan Syndrome (PAMS), is the most severe and life-threatening clinical variant of pemphigus that is characterized by muco-cutaneous and poly organ involvement in association with malignancies of mostly lymphoproliferative origin. The diagnosis of PNP/PAMS must meet definite clinical, histological and immunological criteria and requires highly specific immunohistochemical and immunoserological techniques. Rarely, apart from the associated malignancy, PNP/PAMS may be related to the cytotoxic therapy for its treatment. We observed a case of PNP/PAMS in a 74-year-old man with chronic lymphocytic leukaemia after administration of chlorambucil.
Address for correspondence:
K. Drenovska
Department of Dermatology and Venereology,
UMHAT „Alehandrovska”
1, „ St. Georgi Sofiyski ”, Str.
1431, Sofia, Bulgaria