Issue 2/2025
Erdinchova, Y., Petrova, G.
Department of Pediatrics, University Hospital “Aleksandrovska”;
Department of Pediatrics, Medical University of Sofia
Streptococcal infections are attracting increasing attention, as health agencies around the world recorded a surge in the incidence of severe invasive streptococcal infections (iGAS) in late 2022 and 2023, after a period of low incidence during the years of the COVID-19 pandemic. Their clinical presentation ranges from asymptomatic infections and relatively mild infections such as impetigo, pharyngitis, and scarlet fever to invasive infections such as pneumonia, streptococcal toxic shock syndrome, necrotizing fasciitis, cellulitis, osteomyelitis, as well as autoimmune diseases, which can be fatal. To date, GAS remain susceptible to penicillins. More and more countries are reporting increasing resistance of streptococcal bacteria to macrolide antibiotics.
Key words: skin infections, invasive infections, penicillins, macrolide resistance
Address for correspondence:
Erdinchova, Y.
University Hospital „Aleksandrovska“, Clinic of Pediatrics
1, St. Georgi Sofiyski, Str.
1000, Sofia