Issue 7/2026
Yankova, М., Mateeva, V., Tomov, Т., Mateev, G., Drenovska, К., Dourmishev, L.
Department of Dermatology and Venereology, Medical University – Sofia
Neurofibromatoses are a group of hereditary neurocutaneous disorders, including neurofibromatosis type 1,
neurofibromatosis type 2, and schwannomatoses. A hallmark of these conditions is the development of benign or malignant tumors arising from the peripheral nerve sheath. As with many genetic diseases, neurofibromatoses are associated with multisystem involvement and a broad spectrum of clinical manifestations, which may become apparent from infancy to late adulthood. Cutaneous manifestations are among the earliest and most characteristic clinical features and have an essential role in early recognition and the diagnostic evaluation. The aim of this article is to review the cutaneous manifestations of the most common subtype – neurofibromatosis type 1, and to emphasize the importance of early recognition and diagnosis of the disease.
Key words: neorofibromatosis, cutaneus manifestations, café-au-lait macules, genodermatoses
Address for correspondence:
Dr Maria Yankova
Department of Dermatology and Venereology,
MU – Sofia UMHAT “Alexandrovska” EAD
1, „St. Georgi Sofiiski”, Str.
1431, Sofia
e-mail: mariya.yankova1999@gmail.com