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Home / Endocrinology / Bartrer’s Syndrome – review of literature and case report

Bartrer’s Syndrome – review of literature and case report

отGP News публикувано на 01.11.2023 Endocrinology
Синдром на Бартер

Issue 10/2023

Tsonkova, E.,
Head of Department of Pediatrics, UMBAL Kanev JSC – Ruse

Barter’s Syndrome is a rare, autosomal recessive disease with variable genetic forms affecting renal tubular structures. The disease may be observed either in prenatal or in newborns, babies, young children, adolescents and adults. The genetic disorder occur as an error of ionic transport through the ascending loop of Henle. As a esult appear a defect in sodium, chloride and potassium transport, metabolic alkalosis, poliuria, dehydratation.
These processes result in volume contraction and stimulate the rennin – angiotensin II – aldosteron axis. Barter’s syndrome is associated with polyhydramnios, prematurity in the prenatal period. In newborns and later is manifested with dehydratation, failure to thrive, hipokalemic metabolic alkalosis, low levels of sodium and chloride. A special genetic type is associated with sensorineural hearing loss.
The treatment includes a substitution of lacking electrolytes – potassium supplementation, aldosterone antagonist( diuretics), prostaglandin inhibitor.

Key words: Barter’s Syndrome, genetic tubular disorder, hipokalemic metabolic alkalosis, dehydratation.

Address for correspondence:
Tsonkova, E.
Head of the Department of Pediatrics,
UMBAL Kanev JSC,
Ruse, 2 Nezavisimost St., 7th floor  
e-mail: eva_tsonkova@ mail.bg  
phone: +359 888 256 656

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