Karamfilova1, V., Nedeva2, I.
1 Clinic of Endocrinology and Metabolic Diseases, UMBAL „Alexandrovska“, Medical University – Sofia
2 Department of Epidemiology and Hygiene, MF, Medical University-Sofia
Obesity and diabetes mellitus are associated with an increased risk of developing various types of carcinoma. Multiple factors contribute to the progression of carcinogenesis in obesity and type 2 diabetes mellitus (T2DM), including hyperinsulinemia, insulin-like growth factor 1 (IGF1), hyperglycemia, dyslipidemia, adipokines and cytokines, and the gut microbiome. Weight reduction and T2DM therapy can reduce the risk of developing a number of malignant diseases, as well as their progression. In this review, we summarize the available evidence that describes the complex relationship between obesity, diabetes and carcinogenesis, considering current epidemiological and pathophysiological data, as well as the role of some antidiabetic agents. The bidirectional relationship for the risk of developing diabetes mellitus in certain types of carcinomas is also presented.
Key words: obesity, diabetes mellitus, hyperinsulinemia, carcinomas
Address for correspondence:
Clinic of Endocrinology and Metabolic Diseases,
Medical University – Sofia
1, „Sveti Guerogui Sofyiski“, Str.