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Home / Pediatrics / Challenges in the search for biomarkers in autism spectrum disorders

Challenges in the search for biomarkers in autism spectrum disorders

отGP News публикувано на 29.06.2025 Pediatrics
генетиката на аутизма

Issue 3/2025

Ivanova, E.
University Hospital „Alexandrovska“, Faculty of Medicine,
Medical University – Sofia

The object of the study was two groups of children with autism spectrum disorders (ASD): 9 children (6 boys and 3 girls) with ASD autism and hyperserotonia born to mothers with thrombophilia (first group), and 62 (51 boys and 11 girls) children with ASD without a family history of thrombosis (second group). The average age of the first group is 45.78 months, and the second group – 48.42 months. The results of the assessment reveal the presence of deficits that affect both cognitive capabilities and socio-communication skills, but to a significantly more severe extent.
The study has a number of limitations due to the very small number of patients with ASD and hyperserotonia born to mothers with thrombophilia. Further studies of platelets, hyperserotonones, and coagulation disorders are needed among a larger number of participants, including children with ASD, their parents, and siblings.
Key words: autism spectrum disorders, biomarkers, thrombophilia, serotonin, platelet dysfunction.

Address for correspondence:
Assoc. Prof. Dr. E. Ivanova, MD  
University Hospital „Aleksandrovska“,
Department of Psychiatry 
„St. G. Sofiyski“, Blvd.
e-mail: helen_aivan@abv.bg

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