Issue 2/2025
Vasilev, T., Temelkova, K., Ganeva, M., Kibarova-Hristova, D.,
Dasheva-Dimitrova, A., Stefanov, St.
Clinic of Rheumatology, Children’s Hospital “Ivan Mitev” – Sofia, Department of Pediatrics, Medical University – Sofia
Systemic connective tissue diseases are a group of autoimmune rheumatic diseases characterized by heterogeneous clinical manifestations, that affect connective tissue and lead to systemic inflammation and multi-organ impairment. These diseases include conditions such as juvenile systemic lupus erythematosus, juvenile dermatomyositis, and scleroderma (localized scleroderma and systemic sclerosis), which are recognized as some of the most prevalent systemic connective tissue diseases (sCTDs) throughout the pediatric population. Despite the advancements in contemporary medical practices that offer significant potential in the management of these pathological conditions, corticosteroids have been acknowledged as the fundamental element of therapeutic intervention, facilitating essential immunosuppression and anti-inflammatory effects. Chronic exposure to glucocorticoids can lead to various side effects and complications. One of the most alarming consequences is the emergence of diabetes mellitus induced by steroid usage, as elucidated in the clinical case report that we submit for consideration.
Address for correspondence:
Dr. Teodor Vasilev
Clinic of Rheumatology,
Children’s Hospital „Ivan Mitev” – Sofia
11, „Аcad. Ivan Geshov“, Blvd.
1612, Sofia
e-mail: tvasilev@medfac.mu-sofia.bg