Issue 9/2022
V. Reshkova
(AIRD) are connected with a higher risk from cardiovascular complications and death. They lead to secondary or accelerated atherosclerosis due to autoimmune and inflammatory mechanisms, which are aggravated AIRD by usage of specific drugs – cortitosteroids. At the AIRD the cells components secrete in the atherosclerosic plaque cytokines like TNF alpha, platelet growth factor. The presents of the antibodies is increased at atherosclerosis and rheumatoid and psoriatic arthritis, systematic sclerosis, systematic vasculitides and SLE. At rheumatoid arthritis (RA) is established increase on arterial hardness and artetial blood pressure. The chronic systemic vasculitis at rheumatoid arthritis damages the endothelial function of the vessels. In the patients with illness on coronary vessels and RA have the concentration of the proinflammatory CD4+CD28 null Т-cells seven times more than patients with angina pectoris and acute coronary syndrome. At psoriasis vulgaris is established increased antigen presentation of activated T-cells, T-helper cells answer type-1 and markers on the systemic inflammation. They are preposition for development on atherosclerosis and heart attacks. The chronic inflammation at psoriasis vulgaris has unfavorable effect on the cardiovascular risks profile: oxidative stress, dyslipidemia, endothelial cells dysfunction, adhesion on platelet in the blood.
There is a relationship between inflammatory joint and large number cardiovascular diseases – arterial hypertencion, metabolic syndrome, ischemic illness in the heart, cerebrovascular disease, dementia, preeclampsia and renal diseases. It’s proven a narrow connection between rheumatic diseases and cardiovascular risk.
Address for correspondence:
V. Reshkova
Medical university, “St. Ivan Rilski”
Multiprofile University Hospital for Active
Treatment, Rheumatology Clinic
1612, Sofia, Bulgaria
13, ”Urvich” Str.
e-mail: v_reshkova@abv.bg
tel.: 0878 622 443